Exploring CDKL5 Impact on Extracellular Vesicle-Mediated Cell-to-Cell Communication: Uncovering Hidden Pathways and Innovative Therapeutic Avenues

MDBRCDKL5
Written By Million Dollar Bike Ride

Awardee: Maurizio Giustetto

Institution: University of Torino

Grant Amount: $60,960.00

Funding Period: February 1, 2024 - January 31, 2025

Summary:

The main objective of this study is to explore the potential role of CDKL5 in extracellular vesicles (EVs)-mediated cell-to-cell communication and the consequences of CDKL5 mutation. Newly generated data obtained in our lab, thanks to previous financial support from MDBR, disclosed a restricted panel of EV-miRNAs with an altered expression both in CDD patients’ saliva and in murine CDKL5 mutant neurons cultures. Although these findings suggested that CDKL5 is involved in the composition of EVs cargo content, the consequences of these changes are still unknown.

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