Characterization and correction of Cdkl5 nuclear function in human CDD neurons during maturation

CDKL5CDKL5 Pilot Grant Programme

Sep 1

Written By Million Dollar Bike Ride

Awardee: Simone DiGiovanni, MD, PhD

Institution: Imperial College London

Award Amount: $149,277

CDKL52020

Million Dollar Bike Ride

Nucleic acid binding by ZC4H2

Elucidate the neural mechanisms underlying sleep disturbances and the relation between seizures and sleep-wake cycle in CDKL5 deficiency disorder (CDD)