Targeted reactivation of ZC4H2 using miniature Cas editors
Awardee: Julian Halmai
Institution: University of California, Davis
Grant Amount: $46,846.00
Funding Period: February 1, 2023 - January 31, 2024
Summary:
The overall goal of this proposal is to develop CRISPR therapeutics for ZC4H2 Associated Rare Disorders. If successful, reactivation of the X-linked ZC4H2 could result in rescue of disease associated phenotypes in female patients affected by the disorder. This proposal utilizes AAV ready miniature epigenome editors that have great potential to improve the field of extant CRISPR therapeutics.