Development of 3D ADLD microfiber and organoid models for studying biomarkers and drug testing

JumpstartGrant Assistance Program2023ADLD
Written By Million Dollar Bike Ride

Awardee: Stefano Ratti

Institution: University of Bologna

Grant Amount: $50,000

Funding Period: May 1, 2023 - April 30, 2024

Summary: The project aims at developing reliable ADLD microfiber and organoid models for investigating
biomarkers and for drug testing. The novel models to be developed with this substantial 1 -year funding include 3D microfiber co-cultures of astrocytes and oligodendrocyte precursors (OPCs) and brain organoids. These models will be created from the fibroblasts of patients with the LMNB1 gene duplication and deletion phenotypes and healthy donors.  

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Analyzing CNS cell type specific transcriptomics in ADLD