Development of the novel treatment of idiopathic multicentric Castleman Disease using patientderived cell transplantation in an immunodeficient mouse

MDBRCastleman
Written By Million Dollar Bike Ride

Awardee: Takuya Harada

Institution: National Hospital Organization Kyushu Medical Center

Grant Amount: $63,270.00

Funding Period: February 1, 2024 - January 31, 2025

Summary:

We have established a patient-derived xenograft (PDX) mouse model of idiopathic multicentric Castleman disease (iMCD). Through preliminary research on these mice, we have discovered the contribution of specific immune cells called peripheral helper T (Tph) cells to the pathophysiology of iMCD. By examining the dynamics of these cells in both patients and the mouse model, we are studying further research to understanding the pathophysiology of iMCD.

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