Pain and Analgesic Mechanisms in a Mouse Model of Fibrous Dysplasia

MDBRFDMAS
Written By Million Dollar Bike Ride

Awardee: Anne-Marie Heegaard

Institution: University of Copenhagen

Grant Amount: $80,000.00

Funding Period: February 1, 2023 - January 31, 2024

Summary:

Pain is common and difficult to control symptom for many fibrous dysplasia patients. We have investigated a mouse model of fibrous dysplasia and found that the mice display pain-related behaviors. We have also found that the mice with painful fibrous dysplasia have changes in the peripheral nervous system and an increased expression of factors, which might contribute to the pain. Therefore, the goal of this project is to use the fibrous dysplasia mouse model to further investigate the mechanisms underlying pain in fibrous dysplasia and to test new treatment avenues.

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Investigating key clinical aspects of Fibrous dysplasia of bone in a transgenic mouse model (EF1a-GsαR201C mice) of the disease: pain, effect of anti-resorptive treatments and “rebound” phenomenon.
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