Testing the specificity and efficacy of compounds that inhibit cAMP signaling, for the development of potential therapeutics for FD/MAS

Awardee: Fernando Fierro

Institution: University of California Davis

Grant Amount: $80,642.00

Funding Period: February 1, 2024 - January 31, 2025


Summary:

The Hoffman and Fierro laboratories would like to continue testing compounds to inhibit the excess cAMP production seen in FD/MAS. Proposed studies focus on testing the efficacy and specificity of small molecules, including some candidates identified in the laboratory of our collaborators at UCSF.

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Combinations of small molecule as potential therapeutic agents for APBD

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Spatial transcriptomics to elucidate the mechanism of anti-RANKL inhibition of fibrous dysplasia bone lesions