Grants
Million Dollar Bike Ride 2022 Pilot Grant Program - LOI
The ODC is offering 41 research opportunities focusing on 30 different rare diseases. This program provides a one-year grant to support research related to a rare disease represented in the 2022 Million Dollar Bike Ride. Number of awards and dollar amounts vary per disease based on fundraising totals by each disease team.
Extended deadline for specific diseases: Letter of Interest (LOI) Applications are Due Friday, October 7th, 2022 by 8pm EST
To Apply:
Please review the Request for Applications (RFA)
Complete the Application Form on Submittable.
The MDBR 2022 Pilot Grants are open to the international community holding a faculty‐level appointment at an academic institution or a senior scientific position at a non-profit institution or foundation
Research Areas for the 2022 MDBR Grant Program:
Million Dollar Bike Ride 2022 Pilot Grant Program - Full Application
The ODC is offering 41 research opportunities focusing on 30 different rare diseases. This program provides a one-year grant to support research related to a rare disease represented in the 2022 Million Dollar Bike Ride. Number of awards and dollar amounts vary per disease based on fundraising totals by each disease team.
The MDBR 2022 Pilot Grants are open to the international community holding a faculty‐level appointment at an academic institution or a senior scientific position at a non-profit institution or foundation
Full Application (by invitation only) are Due Monday, October 17, 2022 by 8 PM EST.
To Apply:
Step 1 - Please review the 2022 MDBR Pilot Grant Program RFA Guidelines.
Step 2 - Download and complete the below forms:
Step 3 - Complete the Application Form on Submittable.
Research Areas for the 2022 MDBR Grant Program:
2022 MPS I PILOT GRANT PROGRAM
2022 MPS I PILOT GRANT PROGRAM
Overview
One-year grants up to $150,000 (direct costs) will be available to develop novel treatments for MPS I. The proposed therapeutic strategies should address the unmet needs of CNS manifestations of MPS I in patients with the severe and attenuated forms of the disease. Approaches that also address the somatic manifestations of the disease including the eye, bone, connective-tissue, and heart, which not effectively treated with enzyme replacement therapy or bone marrow transplantation are welcome.
The applicant must have a proven track record in the development of novel therapeutics that progress toward clinical applications. The applicant must demonstrate utility of the proposed therapeutic platform in MPS I animal models during the course of the grant. A second year of funding is possible but should not be incorporated into the initial application.
Eligibility
All individuals holding a faculty‐level appointment at an academic institution or a senior scientific position at a non-profit institution or foundation are eligible to respond to this RFA.
Full Application (by invitation only) are Due Monday, October 17, 2022 by 8 PM EST.
To Apply:
Step 1 - Please review the "Full Application Instructions and Review Procedure" section of the 2022 MPS I Pilot Grant Program RFA Guidelines.
Step 2 - Download and complete the below forms:
Step 3 - Complete the Application Form on Submittable.
For any scientific inquiries regarding this grant please email Cara M. Weismann PhD.
For any administrative inquiries regarding this grant please email Samantha Charleston.
Bloom Syndrome Grant Program
Bloom Syndrome Grant Program
The Orphan Disease Center (ODC) at the University of Pennsylvania is pleased to announce the Bloom Syndrome Grant Program. Bloom syndrome is an ultra-rare multi system disorder that substantially increases the risk of developing cancer at an early age. While only about ~300 cases have been reported to date, Bloom syndrome is part of a group of rare DNA damage response and repair disorders. BLM pathogenic variants that cause Bloom syndrome results in DNA repair defects which results in a chromosome breaks and rearrangements. The abnormal DNA repair is responsible for the increased risk for cancer. Greater knowledge of its mechanisms will be beneficial not only for patients of Bloom syndrome but also could be translated to the clinic for cancer therapy.
We are seeking grant applications that progress the discovery or development of treatments and/or cures for Bloom Syndrome. While the RFA is broad in scope, priority will be given to grants that cover the following areas:
1) Two-year grant for $150,000 (total cost): Improve knowledge of tumor biology, including, but not limited to tumor models, tumor sequencing and tumor signature for Bloom Syndrome, molecular surveillance for tumors, as well as a centralized registry of validated tissue (coordination of sampling, storing and distribution of samples).
2) Two-year grant for $100,000 (total cost): Novel therapeutic approaches for Bloom Syndrome, including, but not limited to, techniques in genome editing, RNA-based mechanisms, biologics, novel cell-based therapeutics, and development of novel therapeutic compounds, including through small molecule repurposing or screening against validated phenotypes in human cellular systems.
Eligibility
Non-profits. All individuals holding a faculty-level appointment at an academic institution or a senior position at a non-profit institution or foundation are eligible to respond to this RFA. Intellectual property created as a result of this funding will be assigned to the home institution of inventors according to standard institutional technology transfer policies. It is expected that these institutions will aggressively license these inventions to appropriate commercial entities with diligence provisions incorporated into these contracts.
Commercial entities. We will accept applications from commercial entities as long as a principal investigator of appropriate experience is identified. Intellectual property created as a result of this funding will be assigned to the home institution of inventors which presumably would be employees of the company. We expect grants provided to commercial entities be matched dollar for dollar. Note that the budget should cover the entire scope of work and should include the ODC award and the company’s match. We will need assurance in the grant contract that the company will diligently complete the project.
This Request for Applications (RFA) is open to all academic scientists and commercial entities in the international research community
Full applications are due Friday, May 27, 2022 by invitation only.
To Apply:
Please review the Bloom Syndrome Grant Program RFA Guidelines.
Complete the Cover Page to be uploaded with full application.
Complete the Budget Form to be uploaded with fill application.
Complete the Application Form on Submittable.
For any scientific inquiries regarding this grant please email Debbie Requesens
For any administrative inquiries regarding this grant please email Samantha Charleston.
2022 CDKL5 Pilot Grant Program Full Application (by invitation only)
The ODC and Loulou Foundation CDKL5 Pilot Grant Program provides a one‐year grant for $150,000.00 (total cost) to support research related to CDKL5 Deficiency Disorder (CDD). The number of awards is not fixed, and may vary.
Full Application (by invitation only) are Due Friday, March 25th, 2022 by 8 PM EST.
To Apply:
Step 1 - Please review the "Full Application Instructions and Review Procedure" section of the 2022 CDKL5 Program of Excellence Pilot Grant Program RFA Guidelines.
Step 2 - Download and complete the below forms:
Step 3 - Complete the Application Form on Submittable.
To review the Loulou Foundation's patent policy please click here
For any scientific inquiries regarding this grant please email Alexis Zavez.
For any administrative inquiries regarding this grant please email Samantha Charleston.
2022 CDKL5 Pilot Grant Program
The ODC and Loulou Foundation CDKL5 Pilot Grant Program provides a one‐year grant for $150,000.00 (total cost) to support research related to CDKL5 Deficiency Disorder (CDD). The number of awards is not fixed, and may vary.
Letter of Intent (LOI) are Due Friday, February 25, 2022 by 5pm EST
To Apply:
Please review the "LOI Instructions and Review Procedure" section of the 2022 CDKL5 Program of Excellence Pilot Grant Program RFA Guidelines.
Complete the Application Form on Submittable.
To review the Loulou Foundation's patent policy please click here
For any scientific inquiries regarding this grant please email Alexis Zavez.
For any administrative inquiries regarding this grant please email Samantha Charleston.
2022 CDKL5 Pilot Grant Program (Copy)
The ODC and Loulou Foundation CDKL5 Pilot Grant Program provides a one‐year grant for $150,000.00 (total cost) to support research related to CDKL5 Deficiency Disorder (CDD). The number of awards is not fixed, and may vary.
Full Application (by invitation only) are Due Friday, March 25th, 2022 by 8 PM EST.
To Apply:
Please review the "Full Application Instructions and Review Procedure" section of the 2022 CDKL5 Program of Excellence Pilot Grant Program RFA Guidelines.
Download and complete the below forms:
Complete the Application Form on Submittable.
To review the Loulou Foundation's patent policy please click here
For any scientific inquiries regarding this grant please email Alexis Zavez.
For any administrative inquiries regarding this grant please email Samantha Charleston.